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饮食通过调节肠道微生物群和促进海马体TRHR表达来对抗发作,影响肠道微生物群

Wenting Xiong¹, Xiaohui Lin¹, Xin Lin¹

¹Department of Neurology, Fujian Province, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Fuzhou, 350001, People's Republic of China.

Journal of molecular neuroscience : MN

|November 3, 2024

概括

性饮食 (KD) 改变了肠道微生物群,减少了多样性,但增强了抗作用. 这种饮食促进海马TRH受体表达,为减少发作提供了一种新的策略.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
代谢障碍代谢障碍代谢障碍

背景情况:

带来了重大的治疗挑战.
性饮食 (KD) 是一种潜在的治疗方法,但其涉及肠道微生物群的机制尚未完全理解.

研究的目的:

为了研究素饮食 (KD) 对肠道微生物群组成的影响.
探索KD诱导的肠道微生物群变化与结局之间的关系.
阐明海马体释放甲状腺素激素受体 (TRHR) 动态在KD疗效中的作用.

主要方法:

来自KD和控制饮食 (CD) 组的小鼠便样本的16S rRNA测序.
来自GEO数据库的差异基因表达的分析.
在体内和体外实验中评估肠道微生物群,KD和海马TRHR相互作用.

主要成果:

与CD相比,KD显著减少了肠道微生物群的多样性.
确定了与G蛋白结合受体相互作用的特定微生物菌株.
肠道微生物群被证实对KD的抗作用至关重要.
突出了神经活性联体受体相互作用途径,特别是TRHR和TRH.
KD增加了海马的TRHR和TRH表达,与减少的神经元放电相关.

结论:

性饮食 (KD) 调节肠道微生物群,影响.
由肠道微生物群变化介导的海马体TRHR表达的增加是KD抗发作效应的关键机制.
这项研究提出了通过KD和肠道微生物群操纵来治疗的新治疗途径.

关键词:

抗药是一种抗药.发生发作的发作.我们的肠道微生物群.河马地区的海马.KD KD KD KD KD KD KD KD KD KD KD KD KD KD KD KD 分子机制的分子机制 TRHR表达式 TRHR表达方式

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