在墨西哥患有青少年异常性关节炎的儿童中,SLCO1B1多态和甲状腺素不耐受之间的关系
Jimena Garcia-Silva1, Beatriz Silva-Ramirez2, Ana V Villarreal-Treviño1
1Departamento de Pediatría, Hospital Universitario "José Eleuterio González", Universidad Autónoma de Nuevo León, Av. Francisco I. Madero Pte. y Av. Gonzalitos, Col. Mitras Centro C.P., 64460, Monterrey, NL, Mexico.
Clinical rheumatology
|November 3, 2024
概括
SLCO1B1基因的遗传变异与青少年异常性关节炎中甲状腺素不良事件有关. *1B单元型增加了副作用的风险,这表明需要优化剂量.
科学领域:
- 药物基因组学 药物基因组学
- 免疫学 免疫学 免疫学
- 儿科风湿病学 儿科风湿病学
背景情况:
- 甲托雷克萨特 (MTX) 的不良事件 (AE),包括胃肠道问题和肝毒性,往往会降低青少年异常性关节炎 (JIA) 的治疗坚持和有效性.
- SLCO1B1基因编码肝脏输送物OATP1B1,影响药物的药理动力学. 在SLCO1B1中的遗传变异可以改变MTX运输,清除和毒性风险.
研究的目的:
- 调查SLCO1B1基因 (rs4149056,rs2306283) 中单核酸多态 (SNPs) 与接受MTX治疗的JIA儿科患者中AEs发生率之间的联系.
主要方法:
- 进行了一项观察性回顾性研究.
- 分析了小儿JIA患者中SLCO1B1基因SNP和MTX相关的AE之间的关系.
主要成果:
- 包括30名JIA患者 (平均年龄为11岁,73.3%为女性);66.7%的患者经历过AEs.
- *1B亚型是普遍存在的 (53.3%) 和显著与增加的风险的AE (OR=3.89,p=0.03) 相关.
结论:
- 患有*1B等位基因的患者可能需要减少MTX剂量.
- 通过SLCO1B1基因定型,可以识别患有MTXAE风险较高的JIA患者,从而实现个性化剂量优化.
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