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性别作为HIV-1和胆囊细胞共感染的生物变量

Jane K Maganga¹, Khanh Pham², John M Changalucha¹

¹Mwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.

The lancet. HIV

|November 3, 2024

概括

生物学性对艾滋病毒-1和瘤共感染的个体的结果产生重大影响. 了解这些性别差异对于推进研究和改善共感染人群中的患者护理至关重要.

科学领域:

传染性疾病传染性疾病
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

艾滋病毒-1和杆菌病是全球健康面临的重大挑战.
同时感染HIV-1和杆菌病影响着全球数百万人.
这些感染之间的相互作用可以影响疾病的进展和结果.

研究的目的:

调查生物性在HIV-1和分裂体共感染中的基本作用.
分析临床结果和感染相互作用的性别特异性差异.
强调将性别作为生物变量纳入未来研究和临床管理的重要性.

主要方法:

对人类纵向和横截面研究的综述.
对共感染的动物模型数据的分析.
综合了关于临床结果,病毒载荷,卵子分泌和死亡率的研究结果.

主要成果:

携带共感染的男性可能有较低的分裂体卵分泌量,但具有较高的HIV-1病毒载荷和肝损伤.
患有瘤感染的女性患有HIV-1感染风险增加,特别是患有Schistosoma haematobium.
同时感染的两性都会向伴侣传播更多的HIV-1病毒;女性面临更高的死亡风险.
生物性别是影响共感染病理生理反应的关键因素.

结论:

性别是艾滋病毒-1和分裂体共感染的临床结果的基本决定因素.
疾病进展,传播和死亡率的性别特异是显而易见的.
未来的研究和临床策略必须整合生物性别,以优化对共感染个体的护理.

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