在含有压缩流体的分离模式的绿色上
Troy T Handlovic1, M Farooq Wahab1, Bailey C Glass1
1Department of Chemistry and Biochemistry, The University of Texas at Arlington, USA.
Analytica chimica acta
|November 3, 2024
概括
液态色谱 (LC) 方法的绿色评价,包括超临界流体色谱 (SFC) 和增强流动性液态色谱 (EFLC),必须考虑仪器循环时间. 经过修改的分析方法绿色度评分 (AMGS) 显示,SFC和EFLC并不总是环境分析中最绿色的选择.
科学领域:
- 分析化学 分析化学
- 环境科学 环境科学
- 绿色化学 绿色化学
背景情况:
- 液体染色学 (LC) 传统上使用有毒有机溶剂,造成环境,健康和安全问题.
- 超临界流体色谱 (SFC) 和增强流动性液体色谱 (EFLC) 被推广为传统逆相 (RPLC) 和正常相 (NPLC) 方法的更绿色替代品.
- 量化绿色评价对于验证不同色谱技术对环境的益处至关重要.
研究的目的:
- 为了量化地评估
- 通过将仪器周期时间纳入评估,批判性地评估各种LC模式 (包括SFC和EFLC) 的绿色度.
- 为分析化学家提供一个工具来选择最环保的分离方法.
主要方法:
- 修改分析方法绿色度评分 (AMGS) 以包括仪器周期时间.
- 应用一级最佳性条件 (AMGS梯度=0) 来确定最佳的绿色.
- 使用修改的AMGS指标对不同LC模式进行比较分析.
主要成果:
- 超临界流体染色学 (SFC) 和增强流动性液体染色学 (EFLC) 并非始终是最绿色的染色学选项.
- 仪器循环时间显著影响整体绿色评分,改变了对流速效率的看法.
- 烟草类酶体的分离证明了在各种保留现象中修改后的指标的实用性.
结论:
- 修改后的AMGS指标为分析化学家提供了一个实用的工具,以评估其分离方法对环境的影响.
- 这种方法有助于通过考虑仪器循环时间来确定常规化学分析中最绿色的分离条件.
- 关于染色学方法选择的知情决定可以使环境负担最小化.
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