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用三甲二化物治疗和肺癌存活率:对代谢重编程的影响

Yap-Hang Chan¹, Cheng Yuen-Ting², Chun-Fung Sin³

¹Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Division of Experimental Medicine and Immunotherapeutics, Cambridge University Hospitals NHS Foundation Trust / University of Cambridge, UK; Department of Cardiology, Royal Papworth Hospital, Cambridge Biomedical Campus, UK; Institute of Cardiovascular Science and Medicine, The University of Hong Kong, Hong Kong SAR, China; Genetics Research Program for Personalized Medicine in Cardiac Oncology, The University of Hong Kong, Hong Kong SAR, China.

Lung cancer (Amsterdam, Netherlands)

|November 3, 2024

概括

在患有肺癌的缺血性心脏病患者中,使用trimetazidine与改善生存率有关,特别是非心血管原因. 需要进一步的随机试验来证实这些发现.

科学领域:

心脏病学心脏病学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

肺癌细胞表现出代谢重编程,有利于脂肪酸氧化.
抑制脂肪酸氧化作用的抗风药物trimetazidine对患有肺癌的缺血性心脏病 (IHD) 患者的临床结果的影响尚不清楚.

研究的目的:

调查三甲素使用与肺癌IHD患者全因死亡率之间的关联.
为了在这个特定的患者群体中比较三甲素使用者和非使用者的生存结果.

主要方法:

一项全境追溯队列研究,涉及香港的279,894名IHD患者 (1999-2020年).
鉴定了6,561名肺癌患者,比较了547名三甲使用者和6,014名非使用者之间的结果.
使用卡普兰-梅尔和考克斯回归模型对所有原因死亡率的纵向分析.

主要成果:

三甲素使用与明显较低的死亡率相关 (79.0%与90.5%,P<0.001).
卡普兰-梅尔分析表明,三甲丁组的平均存活时间更高 (1840.6天对1056.7天,P<0.001).
考克斯回归显示,在使用三甲时,全因死亡风险降低 (HR=0.65,P <0.001),主要与非心血管死亡率有关.

结论:

三甲素的使用与IHD患者的整体存活率的改善有关,这些患者也患有肺癌.
生存益处似乎主要是由非心血管死亡率的降低驱动的.
推随机对照试验来验证这些发现.

关键词:

药物重新定位药物重新定位缺血性心脏病是一种心脏病.肺癌是一种肺癌.代谢重编程是一种代谢重编程.三甲丁是三甲丁的一种.

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