在norfloxacin二次预防中自发细菌性腹膜炎的复发
Athish Shetty1, Rishi Raman1, Vikas Pemmada1
1Department of Gastroenterology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
诺夫洛克萨预防显著减少了自发细菌性腹膜炎 (SBP) 的复发. 复发性SBP显示出较低的抗生素反应率和增加多药耐药生物的趋势.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
背景情况:
- 自发细菌性腹膜炎 (SBP) 是晚期肝病患者的一种严重并发症.
- 使用诺夫洛克萨进行二次预防,以减少SBP复发.
- 关于亚太地区SBP复发率和治疗疗效的数据有限.
研究的目的:
- 评估接受诺弗洛克萨二次预防的患者中SBP复发率.
- 分析SBP复发的特征,治疗反应和风险因素.
- 评估SBP复发对患者死亡率的影响.
主要方法:
- 追溯队列研究涉及112名患者.
- 评估了1年的SBP复发,其概况和对抗生素的反应.
- 确定了SBP复发的风险因素.
主要成果:
- 累积1年SBP复发率在诺夫洛克萨预防中为22.3%.
- 在复发的SBP中,培养阳性为48%,对氏的耐药性为66.6%.
- 复发的危险因素包括年龄,INR和白蛋白水平.
结论:
- 尽管细菌学概况不断变化,但诺夫洛克萨预防仍然有效降低SBP复发率.
- 与第一个发作相比,在复发性SBP中,对 ceftriaxone的治疗反应明显较低.
- 在复发的SBP病例中观察到一种增加多重耐药生物的趋势.
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