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腹状条纹体的LF-DBS缩短了对吗啡位偏好的持久性,并调节海马体中BDNF表达

Mario E Lloret-Torres¹, Jennifer L Barreto-Estrada¹

¹Department of Anatomy and Neurobiology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan 00936, Puerto Rico.

Behavioural brain research

|November 3, 2024

概括

腹腔囊/腹腔条纹体 (VC/VS) 的低频深度大脑刺激 (LF-DBS) 在老鼠中加速了吗啡成的灭绝. 然而,LF-DBS并没有防止复发,这表明它通过海马体变化加强了灭绝记忆.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
分子生物学分子生物学

背景情况:

针对腹腔囊/腹腔条纹体 (VC/VS) 的深度大脑刺激 (DBS) 显示出对物质使用障碍有希望.
以前的研究表明,低频DBS (LF-DBS) 增强了在部分灭绝协议下寻求吗啡的灭绝记忆.

研究的目的:

调查LF-DBS在灭绝训练期间是否有助于灭绝,并防止在完全灭绝协议中恢复药物.
探索分子机制,特别是来自大脑的神经营养因子 (BDNF) 表达,底层的LF-DBS效应.

主要方法:

在动物模型中利用了完全灭绝条件的位置偏好 (CPP) 范式与LF-DBS相结合.
评估了行为结果,并在皮层和内膜膜区域对BDNF进行了西方斑点.
使用BDNF免疫组织化学与逆行追踪器 (CtB) 检查特定的神经通路.

主要成果:

LF-DBS显著减少了对吗啡CPP灭绝所需的时间.
观察到海马BDNF表达的显著增加.
LF-DBS没有阻止药物恢复,并且在特定的投射细胞中没有发现BDNF表达的变化.

结论:

通过增强的灭绝记忆巩固,LF-DBS可以通过减少药物寻找来促进吗啡CPP的灭绝.
海马体内潜在的突触可塑性变化与LF-DBS对记忆强化的影响有关.

关键词:

这就是为什么BDNF是BDNF.灭绝的灭绝灭绝的灭绝在海马体内,海马体低频DBS-低频DBS是什么意思吗啡是一种吗啡.在VS/NAc中使用.

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