聚糖-马蛋白联合化剂可增强安东的生物可用性和稳定性
Havva Aktaş1, Jorge Custodio-Mendoza1, Arkadiusz Szpicer1
1Department of Technique and Food Development, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Warsaw, Poland.
International journal of biological macromolecules
|November 3, 2024
概括
马蛋白分离物 (PPI) 和多糖联物有效地稳定了酸,提高了它们的生物可用性. 这种新的系统为食品和营养药物应用提供了这些有益化合物的更好的输送.
科学领域:
- 食品科学 食品科学 食品科学
- 生物材料工程 生物材料工程
- 营养学药物开发
背景情况:
- 安托素 (ACN) 提供了显著的健康益处,但由于环境因素而变得不稳定.
- 开发稳定的输送系统对于最大限度地发挥安托的治疗潜力至关重要.
- 传统系统在保护这些敏感的生物活性化合物方面存在局限性.
研究的目的:
- 开发和评估一种使用土豆蛋白分离物 (PPI) 和各种多糖化合物稳定酸的新型协系统.
- 与以大豆蛋白为基础的系统相比,评估封装的安托西亚宁的稳定性和生物可用性.
- 为了研究pH值和多糖类型对同性质和素保护的影响.
主要方法:
- 使用PPI与胰岛素,阿拉伯,瓜尔,pectin和可溶性纤维一起形成协体.
- 从黑胡卜缩物中封装的安托西亚宁,在同系统内.
- 评估协生物的稳定性,湿度,水分含量和酸的生物可用性.
- 使用扫描电子显微镜 (SEM) 和里埃变换红外光谱 (FT-IR) 进行表征.
主要成果:
- 在pH 2时观察到最大的土豆蛋白溶解度.
- 马蛋白-guar微囊的水分含量最低,而马蛋白-gum阿拉伯语的水分含量最高.
- SEM和FT-IR证实了成功的微囊形成和蛋白质多糖合并.
- 以PPI为基础的协生物,特别是用牙阿拉伯语和乳清素,显著提高了安东素的稳定性和生物可用性.
结论:
- 基于土豆蛋白分离物的协体系统显示出增强氨酸稳定性和生物可用性的巨大潜力.
- 多糖的选择 (阿拉伯,乳糖) 在协系统的有效性中起着关键作用.
- 这项研究为食品和营养药品行业中生物活性化合物的先进封装技术的开发提供了基础.
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