性和雌性周期对行动结果突发事件的影响
Claire M Corbett1, Samantha L Bozarth1, Elizabeth A West1
1Department of Cell Biology and Neuroscience, Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Virtua Health College of Medicine and Life Sciences of Rowan University, Stratford, NJ, United States; Rowan-Virtua School of Osteopathic Medicine, Virtua Health College of Medicine and Life Sciences of Rowan University, Stratford, NJ, United States.
Behavioural brain research
|November 3, 2024
概括
性和女性雌性周期会影响目标导向的行为. 在应急退化灭绝测试期间,男性表现出比女性更有目标导向的反应,而女性的反应因雌性周期阶段而异.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 动物行为 动物行为
背景情况:
- 目标定向和习惯性行为对于环境导航至关重要.
- 失调,特别是过度依赖习惯性行为,与神经精神疾病 (如物质使用障碍) 有关.
- 应急性退化任务通过将行动与结果脱而出,评估目标导向与习惯性行为.
研究的目的:
- 调查性别和雌性周期对应急降解任务的性能的影响.
- 检查基线焦虑类行为与应急退化灭绝测试中的表现之间的相关性.
- 了解行为灵活性中基于性别和雌性周期的依赖性差异.
主要方法:
- 成年雄性和雌性长埃文斯老鼠被训练在应急降解任务.
- 灭绝测试是为了评估对附带和非附带杆的行为反应进行的.
- 测量了基线焦虑类行为,并记录了女性雌性周期阶段.
主要成果:
- 雄性和雌性大鼠都学会了应急降解任务.
- 在灭绝测试期间,雄性对附带杆的反应比非附带杆的反应更大,而雌性没有显示这种差异.
- 较低的基线焦虑预测男性的表现更好,但女性没有.
- 在孕期和孕期阶段的雌性老鼠对随机杆的反应更大,与雄性相似,与孕期和孕期阶段的雌性不同.
结论:
- 性在应急退化灭绝测试期间影响行为反应.
- 雌性周期显著影响雌性老鼠的行为灵活性,特定阶段 (雌性期,雌性期) 显示出与雄性相似的反应.
- 这些发现强调了在行为神经科学研究中考虑性别和荷尔蒙波动以及理解神经精神疾病的重要性.
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