功能性大脑连接 预测潜在物质使用启动及其环境相关的预测器
Omid Kardan1, Alexander S Weigard2, Lora M Cope2
1Department of Psychiatry, University of Michigan, Ann Arbor, Michigan; Department of Psychology, University of Michigan, Ann Arbor, Michigan.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|November 3, 2024
概括
青少年早期的大脑连接模式预测了物质使用的开始. 这些与加速成熟相关的模式与污染暴露有关,突出显示了对青少年大脑发育和物质使用风险的环境影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 环境健康 环境健康
背景情况:
- 早期开始使用物质 (SUI) 显着增加了以后生活中发展物质使用障碍的风险.
- 青春期是神经发育的关键时期,环境因素可以影响大脑的成熟和易受SUI的影响.
研究的目的:
- 调查青春期前和早期休息状态功能大脑连接 (rsFC) 的纵向模式是否可以预测未来的SUI.
- 确定这些rsFC模式是否与早期环境暴露有关,例如邻里污染和社会经济因素.
主要方法:
- 利用了青少年大脑认知发展 (ABCD) 研究的数据.
- 定义 SUI 是第一次使用酒精,尼古丁,大麻或其他药物.
- 在各种人口因素上,比较了一个SUI组 (n=233) 和一个匹配的对照组 (n=228).
主要成果:
- 从9-10岁到11-12岁的全大脑rsFC模式前性地区分了后来开始使用物质的个人.
- 与SUI相关的已识别的rsFC模式表明在物质使用之前大脑成熟的加速.
- 在一个独立的子样本 (n=2854) 中,较高的邻居污染水平预测了这种rsFC模式,但不是邻居的劣势.
结论:
- 青春期早期的特定大脑功能连接模式,表明加速成熟,可以预测未来的青少年吸毒.
- 这些预测性大脑模式与环境污染暴露有显著的关联.
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