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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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相关实验视频

Updated: Jun 8, 2025

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart
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Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

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长非编码RNAVENTHEART对于心室心肌细胞的特异性和功能是必需的.

Yiqing Yang1, Albert Dashi2, Poh Loong Soong3

  • 1Cardiovascular Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Healthcare Systems, Singapore; NUS Graduate School, National University of Singapore, Singapore.

Journal of molecular and cellular cardiology
|November 3, 2024
PubMed
概括

研究人员确定了VENTHEART (VHRT),一种新的长非编码RNA,对心室心肌细胞发育至关重要. 失去VHRT会损害心室功能,但不会损害心房功能,这突显了它的亚型特异性作用.

关键词:
心脏肌细胞的特征和成熟.心肌细胞收缩的收缩一个单细胞RNAseqqq干细胞衍生的心肌细胞.文字转录 文字转录 文字转录在 lncRNA 中,

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相关实验视频

Last Updated: Jun 8, 2025

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科学领域:

  • 心脏病学 心脏病学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 长非编码RNAs (lncRNAs) 在心肌细胞分化和功能中发挥作用.
  • 关于后期心脏谱系规范和成熟中的lncRNAs的知识是有限的.
  • 目前尚不清楚心房和心室的 lncRNA 表达的差异.

研究的目的:

  • 为了表征一种新型的腹腔肌细胞受限 lncRNA.
  • 研究其在灵长类人心中的保存和功能.
  • 确定其在心房与心室心肌细胞发育中的特定作用.

主要方法:

  • 在2,6和12周对人类多能干细胞衍生心肌细胞 (hPSC-CMs) 的单细胞RNA测序.
  • 权重基因相关性网络分析以确定核心基因模块.
  • 确定 lncRNA (VENTHEART,VHRT) 的CRISPR介导基因删除和随后的功能测定.

主要成果:

  • VENTHEART (VHRT) 被确定为人类心脏中非常丰富的lncRNA,与心室特异性基因 (MYL2,MYH7) 共同表达.
  • 在胎儿和成人心室表达VHRT,但不是心房.
  • 在心室性CM中,VHRT删除损害了瘤形成和心室基因程序,但不是心房性CM,在心室类CM中延长了动作潜力的持续时间.

结论:

  • VENTHEART (VHRT) 是第一个被识别的 lncRNA,它专门用于室内心肌细胞的规范和功能.
  • 这一发现揭示了心室亚型特异性心脏发育的新机制.
  • VHRT的灵长类动物特异性保护表明,它在心室心脏发育中起着重要的进化作用.