在小肠克罗恩病的双气球肠镜检查期间,使用透视镜导管式EUS对深度缓解的评估
Jing Hu1, Guandong Li1, Wei Han1
1Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
在双气球肠镜检查 (DBE-EUS) 期间的透视镜内镜超声波 (EUS) 有效地区分了活跃的小肠克罗恩病 (CD) 和缓解. 用DBE-EUS测量的小肠壁厚度增加与疾病活性相关,有助于患者管理.
科学领域:
- 胃肠病学 胃肠病学
- 内镜成像系统的成像
- 炎症性肠道疾病研究研究
背景情况:
- 在小肠克罗恩病 (CD) 中评估深度缓解提出了挑战.
- 内镜评估对于小肠CD的管理至关重要.
- 区分活跃疾病和小肠CD的缓解需要精确的方法.
研究的目的:
- 在双气球肠镜检查 (DBE-EUS) 期间评估透视镜内镜超声波 (EUS) 的有效性.
- 用DBE-EUS来区分小肠CD患者的内镜缓解和那些患有活跃疾病的患者.
- 评估DBE-EUS在评估小肠CD的跨壁治疗中的作用.
主要方法:
- 接受DBE-EUS的患者根据克罗恩病简单内镜评分 (SES-CD) 被分类为内镜缓解或活动组.
- 使用EUS测量小肠壁厚度,包括全壁厚度 (TWT) 和粘膜下壁厚度 (SMT).
- 进行了统计分析,以比较各组之间的测量结果,并将其与疾病活动指数相关联.
主要成果:
- 与缓解期患者相比,活跃的小肠CD患者的TWT和SMT显著增加 (P < .001).
- 对TWT (2.65毫米) 和SMT (.95毫米) 的切线值显示出高灵敏度和特异性,可以区分活跃和非活跃的疾病.
- TWT和SMT与SES-CD,便calprotectin和克罗恩病活动指数 (所有P < .001) 显示出强烈的正相关性.
结论:
- DBE-EUS对于评估小肠CD的粘膜和外壁愈合是有效的.
- 通过DBE-EUS测量小肠壁厚度,可以准确识别活跃疾病.
- DBE-EUS是治疗小肠克罗恩病患者的一个有前途的工具.
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