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多队列分析揭示了不同种群的结肠直肠癌便样本中的改变的古生物

Tianhui Li¹, Olabisi Oluwabukola Coker¹, Yang Sun²

¹Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.

Gastroenterology

|November 3, 2024

概括

在结肠直肠癌 (CRC) 中,肠道古细胞的组成发生变化. 特定的古生物学物种及其与细菌的相互作用可以作为CRC检测的新生物标志物.

科学领域:

微生物组研究的研究.
我们的肠道微生物群.
考古物 (Archaea) 是一种古老的物种.

背景情况:

古代生物是人类肠道微生物群的关键成员.
它们在结直肠癌 (CRC) 发病过程中的具体作用尚不清楚.

研究的目的:

调查肠道古老菌对CRC发展的贡献.
在CRC的不同阶段分析考古社区的变化.

主要方法:

分析了来自11个队伍的2101名个人 (10个国际,1个内部) 的便元基因组数据.
使用Kraken2和基因组分类数据库进行分类学分析.
考古社区转移,细菌相互作用和甲原功能的调查.
开发一个随机森林模型用于生物标志物识别.

主要成果:

从健康对照 (HCs) 到腺瘤和CRC患者,观察到古老生物多样性的显著转变.
在CRC中发现的Methanobacteriota系的丰富和Methanomassiliicoccales序列的枯竭.
某些物种,如Methanobrevibacter smithii被丰富,而其他物种,包括Methanosphaera stadtmanae,在CRC中被耗尽.
缺乏CRC的古生物体与产生丁酸盐的细菌的同时发生增加.
在CRC患者中,甲基生成途径得到了丰富.
一个结合的古老和细菌生物标记模型在CRC歧视中显示出高精度 (AUC 0.744-0.931).

结论:

多队列分析揭示了肠道古细胞的显著变化及其与HC,腺瘤和CRC患者细菌的相互作用.
肠道古生物学标志物,以及细菌特征,显示出作为CRC的非侵入性诊断工具的希望.

关键词:

考古物 (Archaea) 是一种古老的物种.生物标志物生物标志物结肠直肠癌是什么意思甲的生存细菌_ 一种感染性细菌

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