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Updated: Jun 8, 2025

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
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毒素菌通过通过SREBP2激活来调节胆固醇生物合成和吸收来维持生存

Yi-Min Fan1, Qing-Qi Zhang2, Ming Pan2

  • 1Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, and Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, and Jiangsu Key Laboratory of Zoonosis, Yangzhou, Jiangsu Province, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, PR China.

Journal of lipid research
|November 4, 2024
PubMed
概括

毒素菌感染劫持宿主胆固醇通过上调SREBP2,一个关键的调节器. 抑制SREBP2或胆固醇代谢会损害寄生虫的生长,为毒素菌提供新的治疗点.

关键词:
在HMGCR中,HMGCR是最重要的.这就是LDLR的LDLR.一个人的能力.在SREBP2中,您可以使用SREBP2.这种毒性淋巴细胞 (Toxoplasma gondii) 是胆固醇 胆固醇 胆固醇 是一种

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