第三代测序分析检测出功能性消化不良患者和对照患者之间十二指肠微生物组合的显著差异
Georgios Tziatzios1, Emmanouil Stylianakis2, Georgia Damoraki2
1Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, Athens, Greece.
Neurogastroenterology and motility
|November 4, 2024
概括
与健康对照组相比,功能性消化不良 (FD) 患者表现出改变的十二指肠微生物群多样性和组成. 在FD中,这些肠道微生物组的变化不同于在刺激性肠道综合征 (IBS) 患者中观察到的变化.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 人类健康 人类健康 人类健康
背景情况:
- 功能性消化不良 (FD) 是一种复杂的胃肠道疾病,可能与肠道微生物组的改变有关.
- 十二指肠光含量 (DLC) 微生物组在FD病变发生中的作用需要进一步描述.
研究的目的:
- 为了比较FD患者的十二指肠微生物组形状与健康对照 (CG) 和刺激性肠综合征 (IBS) 患者的微生物组形状.
- 为了确定与FD相关的特定微生物种群在十二指甲膜的亮度.
主要方法:
- 从FD,IBS和CG个体收集了十二指肠吸入物.
- 在牛津纳米孔MiniON上进行16S rRNA基因测序,用于微生物组分析.
- 统计分析了α和β多样性以及微生物种类的相对丰富性.
主要成果:
- 与CG相比,FD患者在DLC中的α多样性显著较低,与IBS患者相似.
- 与CG相比,FD患者中Chloroflexota,Rhodothermota和Thermotogota类的相对丰度在FD患者中较低.
- 在FD和CG组之间,在类,序列,家族,属和物种水平上观察到微生物组成的显著差异.
结论:
- 十二指肠微生物组分析显示,与对照组相比,FD患者的多样性和组成存在显著差异.
- 在FD中观察到的十二指肠微生物组变化与IBS患者中发现的不同.
- 肠道微生物组分析为功能性消化不良的病理生理学提供了洞察力.
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