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2,5-二氧化乙通过影响NFATc1信号通路在体外减弱RANKL介导的骨质结晶发生

Hai-Wei Chen1, Chi-Fen Chen2, Pei-Rong Lee3

  • 1Department of Orthopedic Surgery, Fooyin University Hospital, Pingtung 92849, Taiwan; Department of Medical Laboratory Sciences and Biotechnology, Fooyin University, Kaohsiung 83102, Taiwan.

Bioorganic & medicinal chemistry letters
|November 4, 2024
PubMed
概括

来自Ganoderma bambusicola的2,5-dihydroxyacetophenone (DHAP) 抑制了骨质细胞的分化和骨的再吸收. DHAP特别针对激活的T细胞细胞质1 (NFATc1) 途径的核因子,为治疗骨质损失疾病提供了潜力.

关键词:
2,5-二氧化乙芬二氧化乙芬.抗骨质细胞形成的过程这种植物叫做Ganoderma bambusicola.NFATc1 的使用情况.兰克尔 (Rankl) 是一个名字.

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