智能药丸和药物输送设备使下一代口服剂型成为可能
Carmen Milián-Guimerá1, Reece McCabe1, Lasse Højlund Eklund Thamdrup1
1The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
新型口服药物输送系统,包括3D打印的囊和胃肠道贴片,旨在提高患者的服药性和生物药物生物可用性. 这些创新技术为各种疾病提供个性化医疗解决方案.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 口服剂型是系统治疗的首选,但在患者坚持治疗和生物药物输送方面面临挑战.
- 低生物可用性和患者不良顺应性限制了当前口服疗法的疗效,特别是在频繁使用时.
- 口服和蛋白质药物的有限商业化强调了需要先进的输送策略.
研究的目的:
- 对口服药物输送的新型可摄入毫米尺寸设备和技术进行批判性审查.
- 探索克服传统口服剂型局限性的新兴策略.
- 评估新技术对个性化医疗和改善药物的生物可用性的潜力.
主要方法:
- 对光释放方法的审查,包括3D打印的囊和延长胃内存的剂量形式.
- 研究粘液接口策略,如胃肠道贴片和上皮注射.
- 分析新型口服药物递送技术的当前临床应用和未来市场潜力.
主要成果:
- 亮光释放策略旨在个性化药物,并减少小分子药物的剂量频率.
- 粘液接口策略显示出增强生物宏分子的透性的前景.
- 尽管处于早期发展阶段,但这些新的方法在改善生物可用性和患者遵守性方面显示出有希望的结果.
结论:
- 新的口服药物递送技术,包括可摄入的设备和先进的配方,对于应对当前的治疗挑战至关重要.
- 这些创新对个性化医疗,改善药物的生物可用性和提高患者坚持治疗具有重大潜力.
- 预计持续的研发将使这些有前途的技术从早期阶段进入临床应用.
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