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开发和扩展加卡托普利尔载的电乙烯纤维素纤维,用于持续释放的浮式药物输送
Yuhao Geng1, Gareth R Williams1
1UCL School of Pharmacy, 29 - 39 Brunswick Square, London, WC1N 1AX.
International journal of pharmaceutics
|November 4, 2024
概括
这项研究开发了持续释放的浮式胃保持药物递送系统,使用装载着卡波普利的电乙烯纤维素 (EC) 纤维. 同轴电旋证明了优越的持续释放和减少初始药物爆发,突出显示了其用于先进药物输送的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
背景情况:
- 乙烯纤维素 (EC) 是一种纤维素衍生物,有可能用于药物输送应用.
- 持续释放的胃保留药物输送系统旨在延长药物在胃中的停留时间,以提高治疗效果.
- 电是一种多功能技术,用于制造用于各种应用的聚合物纤维,包括药物输送.
研究的目的:
- 为了制造和表征电乙烯纤维素 (EC) 纤维,加载卡波普利尔,用于持续释放的浮式胃保持药物输送.
- 为了比较单轴和同轴电纤维的药物释放概况和浮动性质.
- 评估在环境储存条件下制造的纤维的稳定性.
主要方法:
- 采用单轴和同轴电技术,以乙纤维素 (EC) 作为矩阵聚合物,并使用普利作为模型药物.
- 探索了基板和扩大规模 (基于针头) 的电方法.
- 纤维形态,药物封装效率,体外药物释放在模拟的胃液中,浮动行为和稳定性被评估使用诸如共聚焦显微镜,X射线衍射和差异扫描热度计等技术.
主要成果:
- 单轴和同轴电纤维均成功制造了圆柱形状和无形药物含量,实现了近100%的封装效率.
- 与单轴纤维和物理混合物相比,同轴电纤维显示出明显减少的初始爆发释放和持续的药物释放概况.
- 所有制造的纤维在24小时以上的模拟胃液中表现出极好的漂浮能力,并在储存8周后保持其无形状态和释放配置文件.
结论:
- 同轴电是一种高效的方法,用于开发持续释放的浮式胃保持药物输送系统,用于使用乙纤维素的托普利.
- 开发的系统显示了通过控制药物释放和延长胃内停留时间来改善药物的生物可用性和患者遵守的有希望的潜力.
- 电纤维的稳定性表明它们适合于实际的制药应用.
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