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相关概念视频

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
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巨细胞激活综合征是什么

Peter A Nigrovic1

  • 1Boston Children's Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Arthritis & rheumatology (Hoboken, N.J.)
|November 4, 2024
PubMed
概括

大细胞激活综合征 (MAS) 是一种严重的免疫过度反应,通常称为细胞因子风暴,可以损害多个器官. 本综述指导理解,识别和管理MAS,特别是在斯蒂尔病中.

科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 儿科 儿科 儿科

背景情况:

  • 巨细胞激活综合征 (MAS) 是一种严重的疾病,其特征是免疫过度激活.
  • 它可以导致严重的,危及生命的多系统末端器官功能障碍,通常被称为"细胞因子风暴".
  • MAS经常与诸如斯蒂尔病,全身性红斑狼和川崎病等类风湿性疾病有关,但也可能发生在感染,恶性瘤和原发性免疫缺陷时.

研究的目的:

  • 为MAS的识别和管理提供实用,基于证据的指南.
  • 主要关注儿童和成人群体中MAS复杂化斯蒂尔病.
  • 提高对MAS的临床理解和及时干预.

主要方法:

  • 本综述综合了当前的证据和临床指南.
  • 它侧重于诊断和治疗的实际方面.
  • 专家的共识和文献审查构成了建议的基础.

主要成果:

  • 由于症状与潜在疾病重叠,MAS存在诊断挑战.
  • 早期识别和迅速,积极的治疗对于改善结果至关重要.
  • 管理策略包括免疫抑制和支持性护理,根据特定的临床环境量身定制.

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Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
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结论:

  • MAS是一种严重的,可能致命的并发症,需要及时识别和管理.
  • 一种系统的诊断和治疗方法,特别是在斯蒂尔病中,可以改善患者的生存率并减少发病率.
  • 需要进一步的研究来完善诊断标准,并优化各种病因的MAS治疗策略.