中和后激活凝血时间和手术后输血在心脏外科手术的结果
Muhammad Arslan Zahid1, Syed Shabbir Ahmed1, Muhammad Saad Yousuf1
1Department of Anaesthesia, The Aga Khan University Hospital, Karachi, Pakistan.
在心脏手术患者中,在蛋白质胺中和后保持激活凝固时间 (ACT) 在基线10%以内,并没有显著改变术后的结果. 这表明,避免积极的蛋白质胺疗法可能会确保血液静止.
科学领域:
- 心血管外科心血管外科
- 麻醉学 麻醉学
- 血液学 血液学 血液学
背景情况:
- 在心肺旁路术后,以逆转氨酸,蛋白胺中和是至关重要的.
- 激活凝血时间 (ACT) 监测指南指导质氨酸的使用.
- 关于患者治疗后的最佳ACT目标仍在争论中.
研究的目的:
- 评估前胺中和后ACT值对心脏外科手术术后术后结果的影响.
- 为了比较维持ACT在基线10%以内的患者与偏差患者之间的结果.
- 评估对胸部排水量,输血需求和重症监护室住院的影响.
主要方法:
- 在101名选择性心脏手术患者的观察性比较研究中.
- 根据与基线相对的前胺后ACT,患者被分为两组.
- 结果包括胸部排水量,输血需求,重症监护室停留,以及需要额外的蛋白质胺.
主要成果:
- 两组之间没有观察到重症监护室停留时间,胸腔排气量或输血率的显著差异 (p >0.05).
- 观察到类似的特兰胺酸使用率和术后重新开放率.
- 基线特征在两组之间是可比的.
结论:
- 维持ACT在基线前胺后中和的10%以内与类似的术后结果有关.
- 这种方法可以避免激进的蛋白质胺疗法,同时确保血液静止.
- 进一步的研究可以探索最佳患者管理的特定ACT门.
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