血清中每和多基基物质水平与与代谢功能障碍相关的脂肪性肝病之间的关联
Jin Zhang1, Xu Cheng1, Yu Wang1
1Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, 430030, Hubei, China.
Environmental pollution (Barking, Essex : 1987)
|November 4, 2024
概括
某些Per-和多醇基物质 (PFAS) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的风险增加有关. 这项研究发现了PFOA和PFNA等特定的PFAS与成年人中更高的MASLD风险之间的关联.
科学领域:
- 环境健康 环境健康
- 肝病学 肝病学是一种肝病学.
- 毒理学 毒理学 毒理学
背景情况:
- 和多基基物质 (PFAS) 是广泛使用的合成化学品,具有潜在的健康影响.
- 以前的研究表明,PFAS可能会引起肝毒性,但流行病学证据仍然不一致.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是与心脏代谢风险因素相关的日益严重的公共卫生问题.
研究的目的:
- 调查暴露于各种PFAS和MASLD的患病率之间的联系.
- 确定可能导致发展MASLD的风险的特定PFAS.
- 提供关于PFAS暴露与肝脏健康之间的联系的流行病学证据.
主要方法:
- 一项涉及1751名参与者的横截面研究,不包括先前存在的肝病或高酒精消耗的个人.
- 在使用超高压液体染色学双重质谱法 (UPLC-MS) 的参与者中量化了30种不同的PFAS.
- 进行了多变量回归分析,以评估PFAS水平和MASLD患病率之间的关联,以肝硬化和心脏代谢风险因素来定义.
主要成果:
- perfluorooctanoic 酸 (PFOA), perfluorononanoic 酸 (PFNA), perfluoroheptanoic 酸 (PFHpA) 和 perfluoroalkyl 碳酸盐 (ΣPFCAs) 的总和与 MASLD 的风险增加有关.
- 在PFOA,PFNA和ΣPFCAs中含量较高的三分之一显示,与最低的三分之一相比,MASLD风险显著增加.
- 8:2化多乙硫酸 (8:2 Cl-PFESA) 与严重脂肪性肝病 (SLD) 和心脏代谢风险因素的反向关联.
结论:
- 特定的PFAS,包括PFOA和PFNA,与MASLD的风险增加有关.
- 这些发现凸显了环境污染物如PFAS在代谢性肝病的发展中的潜在作用.
- 建议进行进一步的前性研究,以确认这些关联并阐明潜在的机制.
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