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使用连贯拉曼显微镜对药物联合结晶的洞察力

Alba M Arbiol Enguita¹, Elina Harju¹, Lea Wurr¹

¹Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, 00790 Helsinki, Finland.

Journal of pharmaceutical sciences

|November 4, 2024

概括

连贯拉曼显微镜,包括CARS和SRS,在液体辅助球磨过程中有效地可视化和量化活性药物成分 (API) 共晶形成,揭示以前未被检测到的形式和过程动态.

科学领域:

制药科学制药科学
化学工程是化学工程的重要组成部分.
材料科学材料科学材料科学

背景情况:

同结晶对于制备活性药物成分 (API) 至关重要.
了解在各种工艺条件下共同结晶的行为,对于成功的配方至关重要.
已建立的分析方法可能无法完全捕捉共同结晶的复杂动态.

研究的目的:

研究连贯拉曼显微镜技术的应用,以研究共结晶.
为了比较窄带连贯抗斯托克斯拉曼散射 (CARS) 和高光谱刺激拉曼散射 (SRS) 进行联合结晶分析.
评估这些技术能够提供对联合结晶过程的定性和定量见解的能力.

主要方法:

液体辅助球磨被用于诱导印米他辛和尼古丁胺胺的联合结晶.
采用了窄带CARS显微镜与一变的峰值位置分析.
使用了高光谱SRS成像与经典最小方程多变量分析相结合.
结果与传统的固态分析方法进行了比较.

主要成果:

窄带CARS可视化了共晶形成,但由于信号混合而面临组件识别方面的挑战.
超光谱SRS成像提供了组件的可靠分离,证明了对定性和定量联合结晶成像的可靠性.
连贯拉曼成像解释了与传统方法不同的终点,并检测了痕迹形式.
这项研究表明,乙醇含量对在加工过程中共同晶体形成逆转的影响.

结论:

连贯拉曼显微镜,特别是SRS,是分析联合结晶过程的宝贵工具.
这些技术为共同晶体形成提供了更深入的见解,包括检测微量成分和过程动态.
这些发现强调了连贯拉曼显微镜在制药配方开发中的附加值.

关键词:

分析化学是一种分析化学.共同晶体 (s) 的图像制造方法 (图像制造)材料科学是一种材料科学.磨削磨削的方法磨削阶段转换的过程水溶性较差的药物 (s)拉曼光谱法拉曼光谱法拉曼光谱法固态硬件是一种固态硬件.频谱学是一种光谱学.

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