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相关概念视频

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

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The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and...
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Raman Spectroscopy Instrumentation: Overview01:26

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A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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使用连贯拉曼显微镜对药物联合结晶的洞察力.

Alba M Arbiol Enguita1, Elina Harju1, Lea Wurr1

  • 1Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, 00790 Helsinki, Finland.

Journal of pharmaceutical sciences
|November 4, 2024
PubMed
概括

连贯拉曼显微镜,包括CARS和SRS,在液体辅助球磨过程中有效地可视化和量化活性药物成分 (API) 共晶形成,揭示以前未被检测到的形式和过程动态.

关键词:
分析化学是一种分析化学.共同晶体 (s) 的图像制造方法 (图像制造)材料科学 是一种材料科学.磨削磨削的方法 磨削阶段转换的过程水溶性较差的药物 (s)拉曼光谱法 拉曼光谱法 拉曼光谱法固态硬件是一种固态硬件.频谱学是一种光谱学.

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科学领域:

  • 制药科学 制药科学
  • 化学工程是化学工程的重要组成部分.
  • 材料科学 材料科学 材料科学

背景情况:

  • 同结晶对于制备活性药物成分 (API) 至关重要.
  • 了解在各种工艺条件下共同结晶的行为,对于成功的配方至关重要.
  • 已建立的分析方法可能无法完全捕捉共同结晶的复杂动态.

研究的目的:

  • 研究连贯拉曼显微镜技术的应用,以研究共结晶.
  • 为了比较窄带连贯抗斯托克斯拉曼散射 (CARS) 和高光谱刺激拉曼散射 (SRS) 进行联合结晶分析.
  • 评估这些技术能够提供对联合结晶过程的定性和定量见解的能力.

主要方法:

  • 液体辅助球磨被用于诱导印米他辛和尼古丁胺胺的联合结晶.
  • 采用了窄带CARS显微镜与一变的峰值位置分析.
  • 使用了高光谱SRS成像与经典最小方程多变量分析相结合.
  • 结果与传统的固态分析方法进行了比较.

主要成果:

  • 窄带CARS可视化了共晶形成,但由于信号混合而面临组件识别方面的挑战.
  • 超光谱SRS成像提供了组件的可靠分离,证明了对定性和定量联合结晶成像的可靠性.
  • 连贯拉曼成像解释了与传统方法不同的终点,并检测了痕迹形式.
  • 这项研究表明,乙醇含量对在加工过程中共同晶体形成逆转的影响.

结论:

  • 连贯拉曼显微镜,特别是SRS,是分析联合结晶过程的宝贵工具.
  • 这些技术为共同晶体形成提供了更深入的见解,包括检测微量成分和过程动态.
  • 这些发现强调了连贯拉曼显微镜在制药配方开发中的附加值.