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实体器官移植接受者的癌症死亡率:系统性审查和元分析

Zhipeng Wang¹, Lihong Deng², Wen Hou¹

¹Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China.

Preventive medicine

|November 4, 2024

概括

实体器官移植接受者与普通人群相比,癌症死亡风险增加了一倍. 有针对性的查至关重要,特别是对于东亚女性来说,她们对特定癌症的风险较高.

科学领域:

移植医学移植医学移植医学
在瘤学瘤学.
流行病学流行病学

背景情况:

固体器官移植是一种拯救生命的手术,但接受者可能面临长期的健康风险.
了解这一群体的癌症死亡风险对于移植后护理和公共卫生战略至关重要.

研究的目的:

系统地审查和元分析固体器官移植接受者的癌症死亡风险.
将移植患者的癌症死亡率与普通人群和非移植癌症患者进行比较.

主要方法:

在主要数据库 (PubMed,科学网,MEDLINE,Scopus) 进行全面的文献搜索,截至2024年7月.
包括在任何固体器官移植接受者中报告癌症死亡风险 (标准化死亡率 (SMR) 或危险率 (HR)) 的研究.
对癌症死亡风险的分析相对于一般人群和没有先前移植的癌症患者.

主要成果:

实体器官移植接受者与普通人群相比,癌症死亡风险增加2.06倍.
在接受脏 (SMR 1.92),肝脏 (SMR 3.07) 和肺/心脏 (SMR 4.87) 移植者中观察到较高的风险.
与其他地区 (SMR 1.16) 相比,东亚女性移植接受者对乳腺,卵巢,子宫和子宫癌的死亡风险明显更高 (SMR 3.13).

结论:

固体器官移植接受者面临的癌症死亡风险要高得多.
对于移植接受者来说,需要加强有针对性的癌症查和干预措施.
应特别注意来自东亚的女性移植接受者,因为她们的癌症死亡风险较高.

关键词:

癌症癌症癌症癌症进行元分析分析.死亡风险死亡风险实体器官移植接受者实体器官移植接受者标准化的死亡率比率.

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