孤儿基因不是一个独特的生物实体
Andres Barboza Pereira1,2, Matthew Marano2, Ramya Bathala3
1Interdisciplinary Graduate Program in Genetics & Genomics, Texas A&M University, College Station, Texas, USA.
概括
孤儿基因,曾经被认为是物种特异性的,是一个多样化的群体,具有不同的进化起源. 这种异质性使它们不适合研究基因进化或表型创新.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 生物信息学是一种生物信息学.
背景情况:
- 基因组测序揭示了许多独特的基因,这些基因对物种适应和进化至关重要.
- 孤儿基因,定义为无基因组同质性的蛋白质编码序列,通常被认为是特定于物种的.
研究的目的:
- 批判性地评估孤儿基因的进化年龄和起源.
- 确定孤儿基因是否适合研究基因进化和表型创新.
主要方法:
- 对分类学,遗传学和序列进化数据的分析.
- 对基因起源机制的证据的评估.
主要成果:
- 孤儿基因表现出广泛的进化年龄,不属于单一的血统.
- 孤儿基因的基因诞生机制多样化,包括横向基因转移,可转移元素化和过度打印.
结论:
- 孤儿基因代表了一个异质的集合,而不是一个单一的生物实体.
- 孤儿基因的不同起源和年龄,排除了它们作为物种特异性基因的有效代理或研究表型创新的有效使用.
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