与心血管生物假体被Mycobacterium chelonae污染相关的内心炎:一个合作的微生物研究
Judith Kikhney1, Inna Friesen2, Solveigh Wiesener3
1Institute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany; MoKi Analytics, Berlin, Germany.
The Lancet. Microbe
|November 4, 2024
概括
黑龙菌可能会殖民于BioIntegral生物假体,导致功能障碍. 这种感染通常被标准诊断错过,并且需要在这些植入物患者中考虑.
科学领域:
- 心血管外科心血管外科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 黑龙菌 (Mycobacterium chelonae) 是一种不常见的感染性内心炎的原因,具有诊断和治疗方面的挑战.
- 研究了M. chelonae在心血管假体功能障碍和生物假体污染中的作用.
研究的目的:
- 为了调查M. chelonae. 生物整体生物假体的潜在殖民.
- 为了确定M. chelonae作为心血管假体功能障碍和感染的原因.
主要方法:
- 在BioIntegral生物假体植入后,参与9名患有M. chelonae感染的患者的合作微生物学研究.
- 利用光现场杂交 (FISH) 与16S rRNA基因测序 (FISHseq) 结合在原生组织,扩展和未使用的生物假体上.
- 通过酸速细菌染色和从M. abscessus.分子分化确认了这些发现.
主要成果:
- 在BioIntegral生物假体中发现的M. chelonae来自三个初始患者和所有12个未使用的假体,尽管有负面培养.
- 欧盟发出警报,导致确定了另外6名患者,在41名患者中,M. chelonae只在BioIntegral产品中检测到.
- 审查了1237个心血管样本,仅在BioIntegral生物假体中发现了M. chelonae.
结论:
- 生物整体生物假体可能含有M. chelonae,可能导致植入物功能障碍.
- 常规诊断可能会忽略M. chelonae感染,并且应怀疑BioIntegral植入物患者.
- 建议向当局报告病例,并重新考虑常规生物假体安全测试.
更多相关视频
07:50An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
Published on: January 7, 2019
6.8K
10:04A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection
Published on: January 7, 2019
6.9K
相关概念视频
01:25Endocarditis I: Introduction
2
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
2
01:18Endocarditis III: Medical Management
2
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
2
01:21Myocarditis I: Introduction
2
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
01:25Endocarditis II: Clinical features and Diagnostic Tests
2
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
01:29Endocarditis IV: Nursing Management
2
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
2
01:23Rheumatic Heart Disease I: Introduction
3
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
3