在轻度中风患者中,大动脉动脉瘤和中风复发:ADS后期分析
Junya Aoki1, Kazumi Kimura1, 1
1Department of Neurology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
概括
大动脉动脉瘤是缺血性中风的来源,与新的大脑病变有关. 与单独使用阿司匹林相比,在轻度中风患者中,联合用西洛斯塔和阿司匹林治疗并没有减少中风复发.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 血管医学 血管医学
背景情况:
- 大动脉动脉瘤是已知的栓塞性中风的来源.
- 经食道心声图 (TEE) 是评估的标准,但具有侵入性.
- 这项研究检查了轻度中风患者的双重抗血小板治疗与大动脉动脉瘤.
研究的目的:
- 评估是否结合西洛斯塔和阿司匹林治疗可以减少轻度中风患者的中风复发.
- 为了比较双重抗血小板治疗与阿司匹林单一治疗在预防新的缺血事件方面的疗效.
主要方法:
- 对急性双重研究数据的后期分析.
- 大动脉动脉瘤定义为内心-中间厚度≥4.0毫米的斑块.
- 脑卒中复发定义为在14天内出现新的扩散权重成像 (DWI) 病变.
主要成果:
- 在316名患者中,有93名患者 (29%) 患有主动脉动脉瘤,与老年和并发症有关.
- 新的DWI病变在大动脉动脉瘤组中更为频繁 (14.1%对6.8%).
- 双重抗血小板治疗 (14.9%) 和阿司匹林 (13.3%) 组之间,新的DWI病变的发生率相似.
结论:
- 大动脉动脉瘤代表系统性动脉样硬化,并与短期新的DWI病变有关.
- 与单独使用阿司匹林相比,在这个队列中,联合基洛斯塔和阿司匹林治疗并没有预防新的DWI病变.
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