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Updated: May 7, 2026

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施用在土壤中的杀虫剂亚酸 (Fosthiazate) 诱导了土虫 (Eisenia fetida) 的氧化应激,神经毒性和转录组异常

Can Wang¹, Xiangfeng Yao², Xianxu Li²

¹College of Resources and Environment, Shandong Agricultural University, Tai'an, Shandong 271018, PR China; College of Natural Resources and Environment, Northwest A＆F University, Yangling 712000, PR China.

Journal of hazardous materials

|November 4, 2024

概括

暴露于亚酸盐会导致氧化应激,DNA损伤和虫 (Eisenia fetida) 的神经系统损伤. 这种杀虫剂也可能诱导亡,炎症和病毒感染,突出显示其生态毒性.

科学领域:

环境毒理学环境毒理学
土壤生态毒理学土壤生态毒理学
有机杀虫剂的作用有机杀虫剂的影响

背景情况:

福斯酸盐是一种常见的土壤杀菌剂,向根结线虫.
它对非目标土壤有机体,如虫的影响,仍然在很大程度上是未知的.

研究的目的:

为了研究亚酸盐对土虫Eisenia fetida的有毒作用.
为了评估氧化应激,DNA损伤和因亚酸盐暴露引起的神经毒性.

主要方法:

使用Eisenia fetida进行了为期28天的暴露实验.
测量反应性氧物种 (ROS),马隆迪化物 (MDA),8-氧-2-脱氧氨酸 (8-OHdG),超氧化物脱氧酶 (SOD) 和催化酶 (CAT) 的活性.
评估乙胆酶 (AChE) 活性和基因表达,由AlphaFold2建模和分子对接支持.

主要成果:

福斯酸盐诱导了显著的氧化应激和DNA损伤,由增加的ROS,MDA和8-OHdG证明,并降低了SOD和CAT活动.
乙胆酶 (AChE) 活性和相关基因表达显著改变,表明神经毒性.
凯格 (KEGG) 分析表明,有可能诱导亡,炎症和病毒感染.

结论:

福斯酸盐对虫构成生态毒理风险,导致氧化应激,DNA损伤和神经毒性.
杀虫剂可能会破坏重要的生物通路,包括亡和免疫反应.
这项研究提供了关于酸对土壤生态系统的环境安全性的关键数据.

关键词:

在AlphaFold2模型中.分子对接是分子对接.神经毒性神经毒性氧化应激是一种氧化应激.文字转录学 (Transcriptomics) 是一个学科.

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