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甲能驱动地肠中的抗生素耐药性

Mengting Qiu¹, Zishan Wu¹, Jiajin Song¹

¹Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Zhejiang Provincial Key Laboratory of Biology of Crop Pathogens and Insects, Institute of Pesticide and Environmental Toxicology, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.

Journal of hazardous materials

|November 4, 2024

概括

杀菌剂残留物,如甲 (CTL) 增加抗生素耐药性基因 (ARG) 在肠. 通过改变肠道细菌和增强移动遗传元素,CTL促进了ARG的传播.

科学领域:

环境科学环境科学
微生物学微生物学
生态毒理学生态毒理学

背景情况:

众所周知,地可以运输环境污染物.
杀菌剂残留物对地肠道微生物群和抗生素耐药性基因 (ARG) 的影响尚不清楚.

研究的目的:

为了研究甲 (CTL) 对虫肠道微生物群和抵抗体的影响.
为了确定CTL如何影响土肠内的ARG的丰富性和类型.

主要方法:

在CTL应用后,对虫肠道内容进行了基因组学分析.
评估CTL在土壤中的消散.
识别ARG宿主和移动遗传元素.

主要成果:

CTL应用改变了虫肠道中的ARG概况,增加了特定ARG (CRP,OXA-427) 的丰度.
CTL减少了细菌的多样性,增加了蛋白质细菌,并可能促进了像Aeromonas这样的病原体.
增强了多种药物排泄基因和ARG的等离子体介导的水平基因转移.

结论:

甲作为一种选择性应激剂,增加了虫肠道中的ARG丰富度.
CTL促进ARG宿主的增殖,并通过等离子体增强ARG的转移.
在杀菌剂压力下,地肠可以成为ARG的储存库.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.虫是地球上的虫.杀菌剂是一种杀菌剂.我们的肠道微生物组.土壤土壤土壤.

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