从饮用水源中提取的化疏水性有机化合物的基因毒性
Binbin Wu1, Yanling Zhang1, Yuehua You2
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Ecotoxicology and environmental safety
|November 4, 2024
概括
化沉积物有机化合物及其分离物在Caco-2细胞中诱导基因毒性和类似于二氧化物的毒性. 水友性化合物是主要的贡献者,抗氧化剂对DNA损伤的保护作用有限.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 沉积物疏水性有机化合物 (HPOC) 是消毒副产品 (DBP) 的前体.
- 了解化HPOCs的基因毒性对于水安全至关重要.
研究的目的:
- 评估化全沉积物 (Cl-WS) 和其分量 (Cl-HOCs,Cl-HICs) 的基因毒性.
- 研究抗氧化剂对DBP诱导毒性的保护作用.
主要方法:
- 化HPOC,然后进行固态提取.
- 卡科-2细胞暴露试验包括反应性氧物种 (ROS) 分析,彗星试验和乙氧化-O-脱乙酶试验.
- 评估抗氧化剂 (catalase,维生素C,EGCG) 的有效性.
主要成果:
- Cl-WS,Cl-HOCs和Cl-HICs诱导了ROS,DNA损伤和类似于二氧化的毒性 (TEQ).
- Cl-HICs是氧化损伤和TEQ的主要贡献者.
- 抗氧化剂降低了ROS,但对DNA损伤和TEQ的影响很小,EGCG对Cl-HIC诱导的DNA损伤有更好的疗效.
结论:
- 化沉积物有机化合物,特别是水友分数,具有显著的基因毒性和类似于二氧化物的风险.
- 抗氧化剂对这些DBP的DNA破坏性和类似于二氧化物的作用提供有限的保护.
- 这项研究为水处理策略提供了关键毒性数据,通过极性区分DBP.
更多相关视频
相关概念视频
01:36Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
01:25Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
00:57The Periodic Table and Organismal Elements
176.7K
Overview
176.7K