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相关概念视频

RNA Structure01:19

RNA Structure

4.7K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
4.7K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.0K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
RNA Interference01:23

RNA Interference

25.9K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
25.9K
Nucleic Acids02:43

Nucleic Acids

43.8K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
43.8K
RNA Stability01:53

RNA Stability

33.3K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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相关实验视频

Updated: Jun 8, 2025

RNA Secondary Structure Prediction Using High-throughput SHAPE
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RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

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通过人工智能预测RNA结构和功能.

Jun Zhang1, Mei Lang2, Yaoqi Zhou2

  • 1National Engineering Laboratory for Big Data System Computing Technology, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China.

Trends in genetics : TIG
|November 4, 2024
PubMed
概括
此摘要是机器生成的。

人工智能 (AI) 正在推进RNA结构预测和功能分析. 将结构和绑定数据与深度学习 (DL) 集成,为RNA序列-结构-功能关系提供了新的见解.

关键词:
设计RNA设计RNA设计功能 RNA 功能 RNA 功能结构 RNA 结构 RNA 结构人工智能的人工智能是人工智能.

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Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

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Last Updated: Jun 8, 2025

RNA Secondary Structure Prediction Using High-throughput SHAPE
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Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen
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Mapping RNA-RNA Interactions Globally Using Biotinylated Psoralen

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科学领域:

  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • RNA分子通过与目标的结构相互作用来执行功能.
  • RNA的动态性质使得实验和计算结构的确定具有挑战性.
  • 人工智能 (AI) 越来越多地应用于RNA研究,包括结构,结合和功能预测.

研究的目的:

  • 探索人工智能的潜力,特别是深度学习 (DL),以了解RNA结构和功能.
  • 突出整合结构和目标绑定信息的重要性,以实现基于人工智能的强大RNA分析.
  • 阐明RNA序列,结构和功能之间的复杂关系.

主要方法:

  • 利用人工智能 (AI) 和深度学习 (DL) 算法.
  • 分析RNA结构动态和目标相互作用.
  • 集成序列,结构和绑定数据用于增强的预测模型.

主要成果:

  • 人工智能在预测RNA结构和功能方面显示出显著的前景.
  • 结合结构和目标绑定信息可以提高人工智能驱动的RNA功能预测和设计的准确性.
  • 深度学习算法为破译RNA序列-结构-功能关系提供了强大的工具.

结论:

  • 人工智能为我们提供了前所未有的机会,以推进我们对RNA生物学的理解.
  • 未来的研究应该专注于将各种数据类型集成到人工智能框架中,以进行全面的RNA分析.
  • 人工智能驱动的方法将彻底改变RNA研究,使得更准确的预测和新的RNA设计成为可能.