年轻人中缺血性中风的发病率增加:2008年至2018年的基于人口的中风注册研究
E Retho1, Y Tasseng1, M Consigny2
1Service de Neurologie, CHRU Cavale-Blanche, Brest, France.
Revue neurologique
|November 4, 2024
概括
在年轻人中,缺血性中风的发生率正在上升,而出血性中风的发生率正在下降. 传统的风险因素无法解释这种趋势,这表明需要探索非传统因素. 这项研究分析了2008-2017年布雷斯特中风登记处中风趋势.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 脑卒中发病率趋势对于公共卫生规划至关重要.
- 布雷斯特中风登记处 (BSR) 为流行病学研究提供基于人口的数据.
- 由于独特的风险因素和潜在的长期影响,关注年轻人 (60岁以下) 中的中风发病率至关重要.
研究的目的:
- 评估布雷斯特地区2008年至2018年首次中风的流行病学趋势.
- 专门分析60岁以下个体中风模式.
- 识别不同年龄组中风亚型 (缺血与出血) 的变化及其潜在原因.
主要方法:
- 从基于人口的布雷斯特中风登记处 (2008-2017) 分析了15岁及以上的首次中风病例.
- 按两年期计算累积发病率,按年龄组和性别分层.
- 使用波桑回归来评估时间趋势,特别关注年轻中风患者和中风机制亚型 (TOAST,SSS-TOAST分类).
主要成果:
- 在10年内,有6043例首次中风;在年轻人 (60岁以下) 中,缺血性中风 (IS) 增加,而脑内出血 (ICH) 减少.
- 在60岁以下的个体中,吸烟,高血压,高酒精摄入量和脂质失调是IS的主要危险因素.
- 尽管改善了包括MRI和血管成像在内的诊断工作,但IS机制亚型的频率保持稳定,传统的风险因素无法解释发病率的增加.
结论:
- 缺血性中风的发生率在年轻人中正在增加,与出血性中风的下降形成鲜明对比.
- 传统的风险因素无法解释年轻人中缺血性中风发病率的上升.
- 对非传统风险因素的进一步研究是有必要的,以了解年轻人中缺血性中风的日益增长趋势.
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