Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

13.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

872
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
872

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Frequent exposure to biologics is associated with small intestinal bacterial overgrowth in patients with Crohn's disease: a retrospective case-control study.

PeerJ·2026
Same author

Effect of Dietary Postbiotics Derived from <i>Lactiplantibacillus plantarum</i> and <i>Pediococcus lactis</i> on Lipid Metabolism, Blood Biochemistry, and Fecal Microbiota in Cats: A Pilot Study.

Veterinary sciences·2026
Same author

Extracellular matrix stiffness in chronic liver disease: From mechanisms to treatments.

Biochemical pharmacology·2026
Same author

Intratumor <i>Lactobacillus</i> drives ferroptosis resistance via D-lactate-STAT3 K631 lactylation in esophageal squamous cell carcinoma.

Gut microbes·2026
Same author

ECM stiffness and epigenetics in organ fibrosis.

Trends in pharmacological sciences·2026
Same author

Research on multi-factor regulation of expansion characteristics in upflow activated carbon filters.

Journal of environmental management·2026

相关实验视频

Updated: Jun 8, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.2K

m6A 糖尿病微血管并发症中的表体转录组修饰.

Li-Chan Lin1, Zhi-Yan Liu1, Jing-Jing Yang2

  • 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.

Trends in pharmacological sciences
|November 4, 2024
PubMed
概括
此摘要是机器生成的。

N6-甲基氨酸 (m6A) 修改调节RNA过程并影响糖尿病并发症. 向m6A酶可能为这些疾病提供新的治疗策略.

关键词:
N6 - 甲基氨酸 (m6A) 的使用.脱甲基酶是什么 脱甲基酶糖尿病微血管并发症标志性转录组学 标志性转录组学甲基转移酶的使用方法

更多相关视频

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

25.7K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

119

相关实验视频

Last Updated: Jun 8, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.2K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

25.7K
Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

119

科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • N6-甲基氨酸 (m6A) 修改是RNA代谢的关键表观遗传调节者.
  • 这些修改影响RNA拼接,翻译和衰变,影响细胞功能.
  • 对m6A的失调越来越多地与各种病理状况有关.

研究的目的:

  • 审查m6A修饰在糖尿病微血管并发症的发病过程中的作用.
  • 探索m6A相关酶 (甲基转移酶,脱甲基酶,结合蛋白) 在这些并发症中的参与.
  • 讨论针对m6A修饰途径的潜在治疗策略.

主要方法:

  • 对调查糖尿病并发症m6A修饰的研究的文献综述.
  • 分析m6A调节酶在糖尿病心肌病,病,视网膜病,神经病和皮肤病中的作用.
  • 综合有关m6A相关治疗点的当前知识.

主要成果:

  • 在糖尿病微血管并发症中,m6A修饰模式发生变化.
  • m6A甲基转移酶,脱甲基酶和结合蛋白在这些并发症的发展中起着重要作用.
  • 特定的m6A相关酶与糖尿病心肌病,病,视网膜病,神经病和皮肤病有关.

结论:

  • m6A的修饰是糖尿病微血管并发症的发病的一个关键因素.
  • 参与m6A调节的酶代表了治疗糖尿病并发症的有希望的治疗点.
  • 对针对m6A的治疗方法的进一步研究可能会导致新的治疗策略.