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相关概念视频

Glucose Transporters01:27

Glucose Transporters

22.5K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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Secondary Active Transport01:32

Secondary Active Transport

6.9K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
6.9K
Glucose Absorption Into the Small Intestine01:26

Glucose Absorption Into the Small Intestine

31.3K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.3K
Translational Regulation01:29

Translational Regulation

1
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
1
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

300
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
300
Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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相关实验视频

Updated: Jun 8, 2025

Demonstration of Heterologous Complexes formed by Golgi-Resident Type III Membrane Proteins using Split Luciferase Complementation Assay
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Demonstration of Heterologous Complexes formed by Golgi-Resident Type III Membrane Proteins using Split Luciferase Complementation Assay

Published on: September 10, 2020

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非编码RNA与SGLT2之间的相互作用:一篇综述

Joanna Jarosz-Popek1, Ceren Eyileten2, Gloria M Gager3

  • 1Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland; Doctoral School, Medical University of Warsaw, Warsaw, Poland.

International journal of cardiology
|November 4, 2024
PubMed
概括

-葡萄糖共运输体2 (SGLT2) 抑制剂提供了除了糖尿病管理之外的心脏和保护性益处. 它们对癌症代谢和分子病理学的影响需要进一步研究潜在机制.

关键词:
癌症 癌症 癌症 癌症心血管疾病的心血管疾病糖尿病 糖尿病 糖尿病脏疾病是一种脏疾病.SGLT2 抑制剂的使用.环RNA 环RNA 是一个环RNA.在ncRNA中,我们可以这是一个小RNARNA.

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Detection of Detergent-sensitive Interactions Between Membrane Proteins
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相关实验视频

Last Updated: Jun 8, 2025

Demonstration of Heterologous Complexes formed by Golgi-Resident Type III Membrane Proteins using Split Luciferase Complementation Assay
05:28

Demonstration of Heterologous Complexes formed by Golgi-Resident Type III Membrane Proteins using Split Luciferase Complementation Assay

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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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Detection of Detergent-sensitive Interactions Between Membrane Proteins
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科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 药理学 药理学 是一个学科.

背景情况:

  • -葡萄糖共运输体2 (SGLT2) 抑制剂是已知的糖尿病降血糖药物.
  • SGLT2 抑制剂显示出全身性心脏和脏保护作用.
  • 目前正在研究SGLT2抑制剂在癌细胞代谢和病理学中的作用.

研究的目的:

  • 探索SGLT2抑制剂心脏和脏保护作用背后的分子机制.
  • 研究SGLT2抑制剂对癌症特征和细胞代谢的影响.
  • 阐明非编码RNAs,特别是微RNAs (miRNAs) 和循环RNAs (circRNAs) 在调解这些效应中的作用.

主要方法:

  • 对SGLT2抑制机制的分析.
  • 研究非编码RNA (ncRNA) 功能,包括miRNA和circRNA.
  • 在转录和转录后层面探索基因调节.

主要成果:

  • SGLT2 抑制剂除了降低葡萄糖水平之外,还具有系统性益处.
  • 像miRNA和circRNA这样的非编码RNA在调节基因表达中起着至关重要的作用.
  • 循环RNAs可以通过菌miRNAs和与蛋白质相互作用来调节基因表达.

结论:

  • 对于SGLT2抑制剂的益处的精确分子机制需要进一步阐明.
  • 非编码RNA是细胞过程和恒温的关键调节者.
  • 了解ncRNA介导的基因调节对于探索SGLT2抑制剂在各种疾病中的应用至关重要.