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Updated: Jul 6, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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开发基于纳米纤维的创新电尼帕菲纳克载荷眼科插件

Safaa Omer1, Nándor Nagy2, Emőke Szőcs2

  • 1University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, Hungary.

International journal of pharmaceutics
|November 4, 2024
PubMed
概括

电纳米纤维网为眼部尼帕芬尼克输送提供了一个有前途的方法. 这些网络显示出良好的溶解性,稳定性和角膜分布,这表明眼科插件的潜力.

关键词:
含有尼帕菲纳克的配方加速稳定性测试试验的时间.细胞相容性研究研究基于电纳米纤维的眼睛插件.体外透性研究在体外溶解研究中的溶解.形态和固态特征的形态和固态特征.

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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...