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胃食道逆流对慢性鼻炎的因果影响:双向的双样本孟德尔随机化研究
Xiang Xin1,2, Yang Yang1,2, Li Xuelei1,2
1Department of Otolaryngology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China.
概括
胃食道逆流 (GER) 因果上增加了慢性鼻炎 (CRS) 和慢性鼻炎 (CR) 的风险. 然而,没有发现GER是由CRS或CR引起的,这表明存在单向因果关系.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 观察性研究表明,胃食道逆流 (GER) 与慢性鼻炎 (CRS) 或慢性鼻炎 (CR) 之间存在联系.
- GER和CRS/CR之间的关联的因果性仍然不清楚.
研究的目的:
- 调查GER和CRS/CR之间的潜在因果关系.
- 使用双向的双样本孟德尔随机化 (MR) 分析.
主要方法:
- 利用来自欧洲和美国祖先种群的综合基因组广泛关联研究 (GWAS) 数据.
- 与GER,CRS和CR作为仪器变量 (IVs) 相关的精选遗传位置.
- 应用了逆方差加权 (IVW) 方法,MR-Egger拦截测试,MR-PLEIOTROPY RESIDUAL SUM AND OUTLIERS (MR-PRESSO) 和留出一个的灵敏度分析来评估因果关系并排除变性和异质性.
主要成果:
- 门德尔的随机化分析表明,GER因果上增加了CRS (OR=1.3795) 和CR (OR=1.3941) 的风险.
- 没有发现反向因果关系的重要证据,CRS或CR不会增加GER的风险.
- 灵敏度分析证实了研究结果的稳定性,没有显示出显著的水平质,异质性或偏差.
结论:
- 基因预测的GER对CRS和CR的风险增加有因果作用.
- 这种关系是单向的,没有证据表明CRS或CR导致GER.
- 调查结果对管理CRS和CR,特别是耐火病例有重大影响.
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