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Updated: Jun 8, 2025

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主体细胞衍生酶的热失活作为多酸盐降解的控制策略

Taku Tsukidate1, Alyssa Q Stiving1, Selina Mengisen2

  • 1Analytical Research & Development Mass Spectrometry.

Journal of pharmaceutical sciences
|November 4, 2024
PubMed
概括

剩余宿主细胞酶导致生物治疗中的聚酸盐降解. 一种新的策略是使用温和的热量来使这些酶失活,从而保存治疗性蛋白质并减少聚酸盐分解.

关键词:
脂酶脂酶是一种mAbAb 在线播放聚酸盐是一种聚酸盐.蛋白质展开的展开过程

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Physical Methods for Controlling Microbial Growth: Temperature01:23

Physical Methods for Controlling Microbial Growth: Temperature

Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
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