氨酸会延迟从奖励下调中恢复,并支持有条件的味觉厌恶
Antonio D R Agüera1, Clara Cándido1, Rocío Donaire1
1Department of Psychology, University of Jaén, Spain.
Pharmacology, biochemistry, and behavior
|November 4, 2024
概括
胺的使用在老鼠中诱导了厌恶状态,增加了在奖励下调任务中的抑制,并引起了味道厌恶. 这些发现表明胺.
科学领域:
- 神经科学是一个神经科学.
- 行为药理学行为药理学
- 动物模型 动物模型
背景情况:
- 胺,一个N-甲基-d-酸盐 (NMDA) 受体对手,表现出抗抑郁药,抗焦虑药和改变记忆的效果.
- 以前的研究表明胺对行为的影响,但其在负面情绪状态中的特定作用需要进一步调查.
- 消耗性连续负对比 (cSNC) 任务为研究丧和厌恶记忆提供了一个模型.
研究的目的:
- 为了研究胺在接受cSNC任务的老鼠的行为影响.
- 为了确定胺是否会加剧意外奖励减少的负面情绪和记忆后果.
- 为了评估胺胺在诱导有条件的味觉厌恶方面的潜力.
主要方法:
- 被限制食物的雄性大鼠接受了cSNC任务的训练,并获得了糖糖奖励.
- 基他胺 (10 mg/kg, ip) 在奖励下调之前或之后被使用.
- 测量了消耗性抑制和糖摄入量;评估了有条件的味觉厌恶.
主要成果:
- 胺的使用,无论是在下调之前还是之后,都显著增加了消耗性抑制.
- 胺注射导致糖糖摄入量减少,表明有厌恶作用.
- 胺诱导了对度较低的糖糖有条件的味道厌恶,独立于cSNC任务.
结论:
- 胺似乎在老鼠中诱导一种厌恶状态.
- 这种胺诱导的厌恶状态可能会增强与cSNC任务中奖励下调相关的挫折感.
- 这些发现支持胺在受条件的味觉厌恶中的作用,并强调了服用时间的重要性.
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