患有唐氏综合征和阻塞性睡眠呼吸暂停的成年人接受了低分泌神经刺激治疗
Phillip Huyett1, Stephanie L Santoro2,3, Nicolas M Oreskovic2,3
1Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
概括
低音神经刺激是对患有唐氏综合征和阻塞性睡眠呼吸暂停 (OSA) 的成年人安全有效的治疗方法. 这种疗法显著减少了呼吸暂停事件,并改善了不耐受正气道压力的患者的氧化.
科学领域:
- 睡眠医学 睡眠医学
- 神经调节是一种神经调节.
- 遗传学和罕见疾病
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 在患有唐氏综合征的成年人中非常普遍.
- 在这种人群中,正气道压力 (PAP) 治疗往往耐受不佳.
- 需要在患有唐氏综合征的成年人中替代治疗OSA.
研究的目的:
- 评估低分泌神经刺激 (HNS) 在患有唐氏综合征和OSA的成年人中的可行性,坚持性和有效性.
- 在这个特定的患者群体中评估HNS的安全性和耐受性.
主要方法:
- 预期招募符合HNS标准的唐氏综合征成年患者.
- 通过基于云计算的合规数据库收集的目标遵守数据.
- 术前和激活后睡眠研究的比较 (至少在激活后3个月).
主要成果:
- 11名患有唐氏综合征的成年人 (平均年龄27岁) 接受了成功的HNS植入.
- 100%的夜间使用时间>4小时和96%的夜间使用时间>8.5小时.
- 呼吸暂停-呼吸暂停指数 (AHI) 中位数减少了76% (从40到9.4事件/小时),所有患者的AHI <15.
- 观察到氧化参数的显著改善.
结论:
- 低分泌神经刺激是一种可行的,安全的,耐受性良好的治疗方法,适用于患有唐氏综合征和中度至重度OSA的成年人.
- 对于不耐受PAP治疗的患者,HNS提供了一种有效的替代方案.
- 这一初始队列证明了HNS在这个人群中的有希望的疗效.
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