胃微生物组组成伴随着与Helicobacter pylori相关的DNA甲基化异常
Takuya Shijimaya1, Tomomitsu Tahara1, Tsubasa Shimogama1
1Third department of internal medicine, Kansai Medical University, Hirakata, Japan.
Epigenomics
|November 4, 2024
概括
胃微生物群多样性影响DNA甲基化. 较低的细菌多样性和Helicobacter pylori感染与胃粘膜中CpG岛的高甲基化增加相关.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- DNA甲基化与胃癌和Helicobacter pylori感染有关.
- 新出现的证据表明,其他胃微生物有助于胃瘤发生.
研究的目的:
- 研究胃粘膜中的细菌群落与H. pylori相关的甲基化异常之间的关系.
- 探索细菌多样性,H. pylori感染和CpG岛 (CGI) 甲基化之间的相关性.
主要方法:
- 16S rRNA测序用于分析来自182名无癌症患者的胃粘膜样本中的细菌群体.
- 结果与特定基因的H. pylori相关的CGI甲基化,LINE1低甲基化和端粒长度相关.
主要成果:
- 较低的细菌α多样性与较高的CGI甲基化相关.
- 高龄,H. pylori感染和较低的细菌α多样性 (香农指数) 与CGI高甲基化显著相关.
- 增加的Helicobacter丰度和减少的Intrasporangiaceae,Macellibacteroides,Peptostreptococcus和Dietziaceae的丰度与高甲基化有关.
结论:
- 研究结果表明,CGI甲基化诱导与H. pylori感染胃粘膜中的细菌α多样性减少之间存在潜在的相关性.
- 这项研究强调了胃微生物组和宿主表观遗传学在H. pylori感染的背景下之间的相互作用.
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