低或高脂肪乳制品和乳制品脂肪对MASLD的不同影响
Oren Tirosh1, Michal Verman1, Dana Ivancovsky-Wajcman2,3
1Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
JHEP reports : innovation in hepatology
|November 4, 2024
概括
低中低脂肪,低糖的乳制品可能会防止与代谢功能障碍相关的脂肪性肝病 (MASLD). 高脂肪的乳制品和饮食可能是有害的,建议为预防MASLD选择更健康的乳制品.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与饮食有关,但乳制品的作用,特别是牛奶脂肪,仍未得到充分研究.
- 关于乳制品消费对MASLD和肝损伤的影响,人类和动物研究有限.
研究的目的:
- 调查乳制品消费与人类MASLD发病率和纤维化标志物之间的关联.
- 评估牛奶脂肪与其他脂肪对动物模型中MASLD的影响.
主要方法:
- 一项为期7年的前性人类队列研究,包括临床评估和饮食问卷.
- 动物研究使用C57BL/6j小鼠进行了12周的高脂肪饮食 (,大豆油,牛奶脂肪).
- 通过超声波或CAP评估的MASLD;FibroTestTM或FibroScan®的纤维化;小鼠的代谢变化和AGE.
主要成果:
- 低中低脂肪,低糖乳制品的高消费与人类MASLD发病率和持续性降低有关 (OR 0.42,p=0.037).
- 高脂肪低糖乳制品的消费与增加的MASLD概率相关.
- 与牛油或大豆油相比,牛奶脂肪在小鼠中增加了血清胆固醇和AGE;所有高脂肪饮食都会引起类似的体重增加和肥胖症.
结论:
- 低至中低脂肪,低糖的乳制品显示出对MASLD的潜在保护作用.
- 高脂肪乳制品和高脂肪饮食与MASLD风险增加有关.
- 关于乳制品脂肪含量的饮食选择对于预防MASLD至关重要.
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