与代谢功能障碍相关的脂肪性肝病相关的纤维化和心脏功能障碍在2型糖尿病患者中
Simona Cernea1,2, Danusia Onișor3,4, Andrada Larisa Roiban5,6
1Department M3/Internal Medicine I, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Târgu Mureş 540142, Romania.
World journal of cardiology
|November 4, 2024
概括
患有2型糖尿病和与代谢功能障碍相关的脂肪性肝病 (MASLD) 肝纤维化患者表现出心脏功能受损,包括较低的射出分数和腹功能障碍的迹象. 晚期肝纤维化与心脏结构变化和心脏功能减弱有关.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与肝纤维化增加心血管风险.
- 在2型糖尿病 (T2DM) 中,MASLD,肝纤维化和心脏健康之间的相互作用需要进一步阐明.
研究的目的:
- 评估MASLD相关肝纤维化T2DM患者的心脏结构和功能变化.
- 调查肝纤维化标志物与心脏参数之间的相关性.
主要方法:
- 对267名患有MASLD的T2DM患者进行了心声学和实验室评估.
- 使用FIB-4和NFS得分量化肝纤维化,将患者分类为晚期纤维化,无纤维化或不确定的风险组.
- 两变和多重回归分析检查了心脏和肝纤维化参数之间的关系.
主要成果:
- 患有晚期纤维化症的患者的肠隔膜厚度增加,左心室 (LV) 后壁厚度增加,心房直径增加,LV质量指数 (LVMi) 增加,心表脂肪组织厚度增加 (EATT).
- 在晚期纤维化组中观察到较低的射出分数 (EF) 和较高的LV壁运动得分.
- 腹筋功能障碍的指标存在,包括高E/e'比率,FIB-4和NFS与心房直径相关. LVMi和LAD显示与血清性激素结合蛋白 (SHBP) 的反相关性.
结论:
- 与MASLD相关的肝纤维化T2DM患者表现出心脏缩,腹功能障碍和EF降低.
- 肝纤维化标志物与心脏结构变化相关.
- 血清SHBP水平与LVMi和左心房直径相反相关,这表明它可能在心肝相互作用中发挥作用.
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