大型抑郁和双极性障碍中来自大脑的神经营养因子和血清素之间的关系:横截面分析
Mian Rohail Hayat1, Muhammad Umair2, Hina Ikhtiar3
1Department of Psychiatry, Mardan Medical Complex, Medical Teaching Institution (MTI), Mardan, PAK.
Cureus
|November 4, 2024
概括
较低的大脑衍生神经营养因子 (BDNF) 水平与主要抑郁症 (MDD) 和双相情感障碍 (BD) 中情绪障碍严重程度的增加相关. 在这项研究中,血清激素水平与症状严重程度没有显著的相关性. BDNF可能是这些疾病的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生物化学
背景情况:
- 情绪障碍,包括主要抑郁症 (MDD) 和双相情绪障碍 (BD),与复杂的脑衍生神经营养因子 (BDNF) 和血清素相互作用有关.
- 虽然研究了个别的作用,但BDNF和血清素在MDD和BD中的联合作用和相互作用仍然不太清楚.
- 这项研究调查了BDNF,血清素和情绪障碍严重程度之间的相互作用,以提供新的见解.
研究的目的:
- 检查MDD和BD患者血清BDNF和血血红水平之间的相关性.
- 评估这些生物标志物相关性如何与MDD和BD的症状严重程度和整体疾病严重程度有关.
主要方法:
- 这是一项涉及63名患有MDD/BD的参与者和21名年龄在18-65岁之间的健康对照者的横截面研究.
- 使用ELISA套件测量血清BDNF和血血水平.
- 用标准化尺度 (HAM-D,YMRS,BDI) 和临床面试 (MINI) 来评估情绪障碍的严重程度.
主要成果:
- 与对照组 (25.9 ng/mL) 相比,在MDD (20.1 ng/mL) 和BD (18.5 ng/mL) 组中观察到较低的BDNF水平.
- 在MDD (r = -0.32,p = 0.045) 和BD (r = -0.28,p = 0.048) 中,BDNF水平和症状严重程度之间发现了显著的负相关性.
- 在这两组中,血血水平与情绪障碍严重程度没有显著的相关性.
结论:
- 降低的BDNF水平与情绪障碍和更严重的症状严重性有关.
- BDNF显示出作为MDD和BD的生物标志物的潜力.
- 需要进一步的研究来澄清血清素在这些疾病中的作用.
相关概念视频
Depression: Overview
221
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
221
Antidepressant Drugs: MAOIs and Other Agents
196
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
196
Depressive Disorders: Etiology
51
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
51
Bipolar Disorder
56
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
56
Brain Imaging
212
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
212
G-protein Coupled Receptors
116.6K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
116.6K


