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线索利德诱导的乳酸化呈现为急性胆囊炎:一个病例报告和系统审查

Fahima Akter¹, Hannah Bozell², Tyson Neumann³

¹Internal Medicine, Indiana University Health Ball Memorial Hospital, Muncie, USA.

|November 4, 2024

概括

利尼佐利德可以引起乳酸,这是一个罕见但严重的副作用. 这项研究突出了线索利德诱导的乳酸酸 (LILA),并建议在乳酸盐水平升高的患者中考虑使用该药物.

科学领域:

传染性疾病传染性疾病
药理学药理学是指药理学的学科.
临界护理医学临界护理医学

背景情况:

莱涅佐利德越来越多地用于治疗多抗药性格拉姆阳性细菌感染.
莱尼佐利德诱导的乳酸酸化 (LILA) 是一种罕见但可能致命的并发症.
迅速识别和停止使用线索利德对于患者的治疗结果至关重要.

研究的目的:

报告LILA病例并进行系统的文献审查.
分析LILA的发病率,风险因素和结果.
强调在差异诊断中考虑LILA的重要性.

主要方法:

一个LILA病例被介绍出来.
使用Medline通过PubMed进行了LILA的系统文献搜索.
从26篇相关文章 (496名患者) 中提取和分析了数据.

主要成果:

在一个患有败血症和乳酸盐水平升高的患者中诊断出LILA,在停止使用linezolid后恢复.
系统性审查包括来自26项研究的496名患者.
在LILA中的死亡率为21.7% (28/129名患者),在停止用线索利德后的生存率有所改善 (30名患者的80%生存率).

结论:

对于用linezolid治疗的患者来说,LILA是一个重大问题,特别是那些患有ESRD,DM,高血压和COPD等并发症的患者.
停止使用线索利德会导致结果的改善.
应将LILA纳入乳酸酸的差异诊断,以减少死亡率.

关键词:

药物反应药物反应乳酸性酸性消化症乳酸性酸性消化症在线zolidlid是什么意思一个Oxazolidinones是一个Oxazolidinones.这就是ZyvoxZyvox.

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