病毒引发的自身免疫与希尔施普朗格病有关,通过激活天生的免疫力
Weiyong Zhong1, Chaoting Lan1, Yuqiong Chen1
1Department of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Children's Medical Research Center, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
病毒感染可能会引发在赫尔施普朗斯的自身免疫.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 赫施普朗氏病 (HSCR) 是肠道神经系统 (ENS) 的一种先天性疾病.
- 遗传因素不能完全解释零星的HSCR病例.
- 感染,自身免疫和先天免疫在HSCR病原发生中的作用需要进一步研究.
研究的目的:
- 为了研究病原体感染,自身抗体和先天免疫激活在希尔施普朗格病之间的关联.
- 探索HSCR的潜在诊断生物标志物.
- 阐明有助于HSCR发展的潜在机制.
主要方法:
- 血清病原体和自身抗体微阵列在新生儿患者和HSCR患者队列与健康对照进行.
- RNA测序 (RNA-seq) 分析了HSCR患者的角质和角质部分的结肠组织.
- 统计分析,包括曲线下面积 (AUC) 计算,用于评估诊断潜力.
主要成果:
- 在HSCR患者中观察到血清IgM和IgG对肠道病毒71 (EV71) 的升高.
- 在HSCR患者中,特异性自身抗体 (NPTX1,粉样蛋白,神经元溶解酸,MOBP) 显著更高,显示出高诊断准确度 (AUC > 0.90).
- 在HSCR中的角质结肠部分表现出广泛的先天免疫通路激活 (TLR,NLR,RLR,cAMP).
结论:
- 病毒触发的自身免疫性与HSCR病原发生有关.
- 天生的免疫系统激活在HSCR发育中起着至关重要的作用.
- 这些发现可能有助于诊断和预防赫施普隆病.
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