螺旋体曼索尼 (Schistosoma mansoni) 感染和肝细胞癌:一种并发症研究
Amal Farahat Allam1, Hoda Fahmy Farag1, Amel Youssef Shehab1
1Department of Parasitology, Medical Research Institute, University of Alexandria, 165 El Horreya avenue, El Hadara, Alexandria, Egypt.
概括
瘤曼索尼 (S. mansoni) 感染,以及型肝炎病毒 (HCV) 和乙型肝炎病毒 (HBV),增强了肝细胞癌 (HCC) 的进展. 这项研究强调了这些感染对肝癌发展的协同影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 在肝细胞癌 (HCC) 的发展中,虫虫 (Schistosoma mansoni) 感染 (S. mansoni) 的作用,特别是与型肝炎病毒 (HCV) 和乙型肝炎病毒 (HBV) 等共感染的作用,仍在争论中.
- 肝细胞癌 (HCC) 是一个重要的全球健康问题,病毒性肝炎和寄生虫感染是关键的风险因素.
研究的目的:
- 调查S. mansoni感染与HCC的发展或进展之间的关联.
- 评估S. mansoni,HCV和HBV对HCC的综合影响.
主要方法:
- 研究包括90名HCC患者,使用Kato-Katz和间接血结 (IHA) 试验评估S. mansoni感染.
- 收集了社会人口统计和临床数据,包括阿尔法胎蛋白 (AFP) 水平,Child-Pugh分数和巴塞罗那诊所肝癌 (BCLC) 阶段.
主要成果:
- 虽然活跃的S. mansoni感染是Kato-Katz负的,但IHA在HCC患者中发现了28例阳性病例.
- 患有S. mansoni的HCC患者显示同时出现HCV的患病率更高 (92.6%) 和胃肠道出血增加了四倍.
- 在S. mansoni阳性HCK患者中,BCLC类D阶段化明显更频繁.
结论:
- 与S. mansoni,HCV和HBV的同时感染似乎加速了HCC的进展.
- 顺病的阳性与更先进的肝癌阶段和增加的并发症有关.
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