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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Updated: Jun 10, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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追求theranostics:一个多式联网架构方法.

Aidan A Bender1, Connor K Holiski1, Mary Embree2

  • 1Nuclear Engineering Program, University of Utah 110 Central Campus Dr. Suite 2000B Salt Lake City UT 84112 USA tara.mastren@utah.edu.

Sensors & diagnostics
|November 4, 2024
PubMed
概括
此摘要是机器生成的。

一个基于素的新型多式架构,通过允许附加诊断和治疗放射性核素,使灵活的治疗应用成为可能. 这种可定制的支架证明了先进核医学的高稳定性和高效放射性标记.

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科学领域:

  • 核医学是一种核医学.
  • 放射化学 放射化学是指辐射化学.
  • 材料科学 材料科学 材料科学

背景情况:

  • 治疗术结合了诊断和治疗,使用相同的向载体和化系统.
  • 目前的超神学方法需要更具适应性的酸盐系统来实现新的准策略.
  • 开发灵活的支架对于推进多模式放射性药品至关重要.

研究的目的:

  • 为theranostic应用程序创建一个多功能,基于基的多式架构.
  • 设计可定制的支架,能够化多个放射性核素.
  • 评估新型多式联络化合物的稳定性和放射性标记效率.

主要方法:

  • 一个六臂酸核心脚手架的合成.
  • 使用点击化学,将DTPA和/或DFO合基因图案连接在一起.
  • 用于发光和结构确认的 terbium 复合物的表征.
  • 用于验证异金属标记能力的金属位移定位.
  • 在体外稳定性评估和放射性标记使用161Tb和89Zr.

主要成果:

  • 两种多模式化合物,pDbDt和pDbDtDf,是使用酸核合成的.
  • 复合体表现出强烈的发光,充当有机天线.
  • 通过金属位移定位证实结构,显示异金属标记潜力.
  • 化合物在体外显示出高的热和生物稳定性.
  • 在用161Tb和89Zr进行放射性标记后获得的高摩尔活性,包括1:1异金属标记.

结论:

  • 开发的基于基的多模式架构为theranostics提供了一个高度可定制的平台.
  • 这种支架有助于诊断和治疗放射性核素的合.
  • 该系统在开发先进的异金属放射性药物方面显示出显著的前景.