耐卡巴耐药格拉姆阴性细菌引起的传染性内心炎 - - 一项系统性审查
Konstantinos Pitsikakis1, Michail Skandalakis1, Konstantinos Fragkiadakis2
1School of Medicine, University of Crete, 71003 Heraklion, Greece.
Germs
|November 4, 2024
概括
感染性内心炎是由耐卡巴胺的格拉姆阴性细菌引起的,是一种严重的感染,死亡率高. 紧急的感染控制和抗菌药物管理对于打击这种威胁至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 传染性内心炎 (IE) 通常涉及格拉姆阳性细菌,但可以由格拉姆阴性细菌引起.
- 抗微生物耐药性 (AMR),特别是对碳烯的耐药性,使IE治疗复杂化,并增加死亡率.
- 耐卡巴胺的格拉姆阴性细菌 (CRGNB) 在医疗机构中构成越来越大的威胁.
研究的目的:
- 系统地审查由CRGNB引起的IE的所有报告病例.
- 分析这种感染的流行病学,临床表现,治疗策略和结果.
主要方法:
- 对PubMed,Cochrane图书馆和Scopus数据库进行了系统审查.
- 包括到2023年8月6日发表的研究,CRGNB对IE的报告.
- 提取了有关患者人口统计,临床发现,病原体,治疗方法和结果的数据.
主要成果:
- 分析了24项涉及26名患者的研究.
- 平均年龄为66岁,其中53.9%是男性;38.5%有假.
- 常见的病原体包括Pseudomonas aeruginosa,Klebsiella pneumoniae和Acinetobacter baumannii. 这些病原体都会导致肺炎. 死亡率为38.5%,为38.5%的人.
结论:
- 由CRGNB引起的IE与显著的发病率和高死亡率有关.
- 有效的感染控制措施和抗菌药物管理对于减轻AMR的影响至关重要.
- 需要进一步的研究和干预措施来解决这种致命的感染.
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