根据阿莫西西林MIC的Enterococcus faecalis感染性内心炎的结果:一个多中心研究
Hermann Do Rego1, Yousra Kherabi1, Stephane Corvec2
1Equipe Mobile de Microbiologie Clinique, Hôpitaux Saint-Joseph & Marie-Lannelongue, Paris, France.
JAC-antimicrobial resistance
|November 4, 2024
概括
较高的阿莫西西林MIC并没有增加Enterococcus faecalis感染性内心炎的死亡风险. 这项研究评估了阿莫西西林.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 在全球范围内,Enterococcus faecalis感染性内心炎的发病率正在上升.
- 关于阿莫西西林最小抑制度 (MIC) 对治疗结果的影响的数据有限.
- 菌 (Enterococcus faecalis) 是感染性内心炎的一个重要原因.
研究的目的:
- 描述Enterococcus faecalis感染性内心炎的流行病学.
- 评估阿莫西西林MIC与这些患者的死亡率之间的关联.
主要方法:
- 在11家法国医院 (2013-2020年) 进行了403名确诊的E. faecalis感染性内心炎患者的回顾性研究.
- 数据从DRG数据库中提取,并与微生物学结果匹配.
- 阿莫西西林MIC通过Etest确定;主要终点是与内心炎相关的死亡率.
主要成果:
- 与内心炎相关的死亡率为28.3%.
- 对246名患者提供阿莫西西林MIC数据;中位数MIC为0.5 mg/L.
- 在多变量分析中,阿莫西西林MIC与住院死亡率无关.
结论:
- 升的阿莫西西林MIC不是Enterococcus faecalis感染性内心炎的死亡风险因素.
- 需要进一步的研究来调查阿莫西西林MIC对疾病复发的影响.
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