早期区域大脑灰质损伤预测多发性硬化症的长期认知障碍表型:20年研究
Stefano Ziccardi1, Francesco Crescenzo2, Maddalena Guandalini1
1Neurology Section, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Brain communications
|November 4, 2024
概括
在特定的大脑区域的早期灰质损失预测了多发性硬化症 (MS) 中的长期认知障碍. 这一发现有助于识别20年内面临认知衰退风险的个体.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 灰质缩与多发性硬化症 (MS) 的认知障碍有关.
- 早期缩对MS中长期认知变化的预测价值仍未得到充分研究.
研究的目的:
- 识别20年多发性硬化症后认知状态的早期预测因素.
- 评估早期区域灰质体积损失与长期认知障碍之间的关联.
主要方法:
- 175名多发性硬化症患者的长度回顾性研究.
- 诊断时的MRI扫描 (T0) 和2年后的MRI扫描 (T2) 来评估区域灰质体积损失.
- 经过平均20年后的综合神经心理评估,对临床和MRI变量进行了调整后的后勤回归分析.
主要成果:
- 47%的患者在20年后表现出认知障碍,记忆力,注意力/处理速度和执行功能的缺陷.
- 早期的灰色物质体积损失在前,胰岛,副海马圈和带预测了全球和特定领域的认知变化.
- 这些地区的调整后赔率比率从1.81到3.37不等,具有显著的p值.
结论:
- 在特定的皮层和深层灰质区域的早期区域灰质体积损失是多发性硬化症中长期认知障碍的重要预测因素.
- 这些发现突显了早期基于MRI的生物标志物的潜力,可以预测MS患者的认知轨迹.
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