scImmOmics:一个手工策划的单细胞多组体免疫数据资源
Yan-Yu Li1,2,3,4,5,6,7, Li-Wei Zhou8, Feng-Cui Qian1,2,3,6
1The First Affiliated Hospital & National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Nucleic acids research
|November 4, 2024
概括
scImmOmics是一个拥有超过290万个免疫细胞的新数据库,为了解免疫细胞多样性和功能提供了全面的资源. 这种单细胞多细胞图谱有助于研究健康和疾病中的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 单细胞测序揭示了对了解健康和疾病至关重要的各种免疫细胞功能.
- 现有的单细胞RNA测序 (scRNA-seq) 数据缺乏统一的,免疫特异的多组图谱.
研究的目的:
- 开发scImmOmics,一个手工策划的,单细胞多细胞免疫数据库.
- 为免疫细胞异质性和调控机制提供一个全面的资源.
主要方法:
- 收集和策划的高质量的免疫细胞与已知的标签.
- 来自七种单细胞测序技术的综合数据.
- 标准化了免疫细胞命名法,并创建了一个层次结构.
主要成果:
- scImmOmics包含超过290万个细胞类型标记的免疫细胞,遍及131种,47种组织和4种物种.
- 该数据库包括T细胞/B细胞受体测序,细胞特异性调控状态和细胞间通信网络.
- 还提供了有关免疫细胞对细胞因子反应的信息.
结论:
- scImmOmics是探索免疫细胞多样性和功能的宝贵平台.
- 它有助于阐明单细胞层面的特定监管机制.
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